{"id":1151,"date":"2025-02-18T03:33:04","date_gmt":"2025-02-18T03:33:04","guid":{"rendered":"https:\/\/kwonlab.chem.ucla.edu\/?page_id=1151"},"modified":"2026-05-22T19:45:01","modified_gmt":"2026-05-22T19:45:01","slug":"publications","status":"publish","type":"page","link":"https:\/\/kwonlab.chem.ucla.edu\/?page_id=1151","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Publications – 12<\/o-anim-count>2<\/h2>\n\n\n\n

122.\u00a0<\/strong>Dehnert, B. W.; Leung, C.; Kwon, O. Fluorodealkenylation: Ozonolysis and Treatment with FeII<\/sup> Salt and Selectfluor Convert C(sp3)\u2013C(sp2<\/sup>) Bonds to C(sp3<\/sup>)\u2013F Bonds. Org. Lett.<\/em> 2026<\/strong>, DOI: 10.1021\/acs.orglett.6c01643. [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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121. <\/strong>Prout, E.S..; Kwon, O.; Silva, T.G. Regioselective Synthesis of Methyl Enol Ethers from Cycloalkanones via O-Methylation of Kinetic Enolates. Synthesis,<\/em> 2026<\/strong>, DOI:10.1055\/a-2822-8676 [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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120. <\/strong>Croll, E. A..; Kwon, O. Organocatalytic Transformations with Chiral Phosphines. Enantioselective Organocatalysis: Catalysts, Reactions, and Applications<\/em>. Dalko, P. I., Ed.; Wiley\u2010VCH GmbH, 2026<\/strong>; pp 803\u2013847. DOI: 10.1002\/9783527845552.ch21. [link<\/a>]<\/p>\n\n\n\n

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119.<\/strong> Dworkin, J. H.; Chen, Z. M.; Prout, E.S.; Kwon, O. Ozonolysis of Alkenes Containing Amines, Allylic Alcohols, and Electron-Rich Arenes for Dealkenylation. Org. Lett.<\/em> 2025<\/strong>, 27<\/em>, 7833\u20137839 DOI: 10.1021\/acs.orglett.5c02076 [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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118.<\/strong> Dworkin, J. H.; Chen, Z. M.; Cheasty, K. C.; Rubio, A. V.; Kwon, O. Hydrodealkenylative C(sp3<\/sup>)\u2013C(sp\u00b2) Bond Fragmentation Using Isayama\u2013Mukaiyama Peroxidation. J. Am. Chem. Soc.<\/em> 2025<\/strong>, 147<\/em>, 13531\u201313544. DOI: 10.1021\/jacs.5c00540. [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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117.<\/strong> \u0160imek, M.; Dworkin, J. H.; Kwon, O. Synthesis through C(sp3<\/sup>)\u2013C(sp\u00b2) Bond Scission in Alkenes and Ketones. Acc. Chem. Res.<\/em> 2025<\/strong>, 58<\/em>, 1547\u20131561. DOI: 10.1021\/acs.accounts.5c00156. [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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116.<\/strong> Champion, O.; Ma\u00efga, S.; Antier, C.; Dousset, C.; Moreau-Aubry, A.; Bellanger, C.; Guillonneau, F.; Moreno, J.A.; Kwon, O.; Lilli, N. L.; Moreau, P.; Chiron, D.; Pellat-Deceunynck, C.; Touzeau, C.; Gomez-Bougie, P. VDAC2 primes Myeloma cells for BAK-dependent apoptosis and represents a novel therapeutic target. Leukemia<\/em> 2025<\/strong>, 39<\/em>, 995\u20131000. DOI: 10.1038\/s41375-025-02523-8 [abstract<\/a>] [link<\/a>]<\/p>\n\n\n\n

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115. <\/strong>\u0160imek, M.; Mahato, S.; Dehnert, B. W.; and Kwon, O. Deacylative Homolysis of Ketone C(sp3<\/sup>)\u2013C(sp\u00b2) Bonds: Streamlining Natural Product Transformations. J. Am. Chem. Soc.<\/em> 2025<\/strong>, 147<\/em>, 2664\u20132674. DOI: 10.1021\/jacs.4c15045 [abstract<\/a>] [pdf<\/a>]    <\/p>\n\n\n\n

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114. <\/strong>Dehnert, B. W.; Yin, Y.; and Kwon, O. Halodealkenylation: Ozonolysis and Catalytic Fe{II} with Vitamin C Convert C(sp3<\/sup>)\u2013C(sp\u00b2) Bonds to C(sp3<\/sup>)\u2013Halide Bonds. Org. Lett.<\/em> 2024<\/strong>, 26<\/em>, 10921\u201310927 DOI: 10.1021\/acs.orglett.4c04084. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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113. <\/strong>Dehnert, B. W.; Kwon, O. Hydrodealkenylative Cleavage of C(sp3<\/sup>)\u2013C(sp\u00b2) Bonds: Preparation of (1S<\/em>, 3R<\/em>)-3-Methylcyclohexan-1-ol. Org. Synth.,<\/em> 2024<\/strong>, 101<\/em>, 488\u2013507. DOI: 10.15227\/orgsyn.101.0488. [abstract<\/a>] [pdf<\/a>]\u200b<\/p>\n\n\n\n

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112. <\/strong>Croll, E. A.; Kwon, O. Mechanism of the Mitsunobu Reaction: An Ongoing Mystery. Synthesis,<\/em> 2024<\/strong>, 56<\/em>, 1843\u20131850. DOI: 10.1055\/a-2232-8633. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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111. <\/strong>Tan, Q.; Kwon, O. [4+2] Cycloadditions Catalyzed by Nucleophilic Catalysts. In Comprehensive Chirality, 2nd Ed., Volume 2. Asymmetric Cycloadditions<\/em>. Feng, X., Ed.; Elsevier, 2024; pp 357\u2013428. DOI: 10.1016\/B978-0-32-390644-9.00045-7. [link<\/a>]<\/p>\n\n\n\n

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110. <\/strong>Dehnert, B. W.; Dworkin, J. H.; Kwon, O. Dealkenylative Functionalization: Conversion of Alkene C(sp3<\/sup>)\u2013C(sp\u00b2) Bonds to C(sp3<\/sup>)\u2013X Bonds via Redox-Based Radical Processes. Synthesis, <\/em>2024<\/strong>, 56<\/em>, 71-86. DOI: 10.1055\/a-2044-4571. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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109. <\/strong>He, Z.; Moreno, T.; Swain, M.; Wu, J.; Kwon, O. Aminodealkenylation: Ozonolysis and copper catalysis convert C(sp3<\/sup>)\u2013C(sp\u00b2) bonds to C(sp3<\/sup>)\u2013N bonds. Science<\/em>, 2023<\/strong>, 381<\/em>, 877\u2013886. DOI: 10.1126\/science.adi4758. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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108. <\/strong>Dworkin, J. H.; Dehnert, B. D.; Kwon, O. When all C\u2013C breaks LO\u2013Ose. Trends Chem.<\/em> 2023<\/strong>, 5, <\/em>174-200. DOI: 10.1016\/j.trechm.2023.01.001 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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107. <\/strong>Xie, C.; Kim, J. M.; Khanh, B.; Cao, S.; Ye, R.; Wang, X.; Liu, P.; Kwon, O. Enantioselective Synthesis of Quaternary Oxindoles: Desymmetrizing Staudinger\u2212aza-Wittig Reaction Enabled by Bespoke HypPhos Oxide Catalyst. J. Am. Chem. Soc.<\/em> 2022<\/strong>, 144<\/em>, 21318\u201321327. DOI: 10.1021\/jacs.2c09421 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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106.<\/strong>  Swain, M.; Bunnell, T. B.; Kim, J. Kwon, O. Dealkenylative Alkynylation Using Catalytic Fe(II) and Vitamin C.  J. Am. Chem. Soc. <\/em>2022<\/strong>, 144<\/em>, 14828\u201314837. DOI: 10.1021\/jacs.2c05980 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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105.<\/strong>  Hagiwara, H; Watanabe, M.; Fujioka, Y.; Kadosaka, T.; Koizumi, T.; Koya, T.; Nakao, M.; Kamada, R.; Temma, T.; Okada, K.; Moreno, J. M.; Kwon, O.; Sabe, H.; Ohba, Y.; Anzai, T. Stimulation of the mitochondrial calcium uniporter mitigates chronic heart failure-associated ventricular arrhythmia in mice. Heart Rhythm<\/em> 2022<\/strong>, 19<\/em>, 1725-1735. DOI: 10.1016\/j.hrthm.2022.05.034. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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104.<\/strong>  Khong, S.; Venkatesh, T.; Kwon, O. Nucleophilic Phosphine Catalysis: The Untold Story. Asian J. Org. Chem. <\/em>2021,<\/strong> 10<\/em>, 2699\u20132608. DOI: 10.1002\/ajoc.202100496. {abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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103.<\/strong>  Shankar, T. S.; Ramadurai, D. K. A.; Steinhorst, K.; Sommakia, S.; Badolia, R.; Krokidi, A. T.; Calder, D.; Navankasattusas, S.; Sander, P.; Kwon, O. S.; Aravamundhan, A.; Ling, J.; Dendorfer, A.; Xie, C.; Kwon, O.; Cheng, E. H. Y.; Whitehead, K. J.; Richardson, R. S.; Spitzer, K. W.; Schdelseker, J.; Chaudhuri, D.; Drakos, S. G. Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nat. Commun<\/em>. 2021<\/strong>, 12<\/em>, 4583. DOI: 10.1038\/s41467-021-24869-0 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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102.<\/strong>  Xie, C.; Smaligo, A. J.; Song, X.-R.; Kwon, O. Phosphorus-Based Catalysis. ACS Cent. Sci.<\/em> 2021<\/strong>, 7<\/em>,  536\u2013558. DOI: 10.1021\/acscentsci.0c01493 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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101.<\/strong> Chen, V. Y.; Kwon, O. Unified Approach to Furan Natural Products via Phosphine\u2013Palladium Catalysis. Angew. Chem. Int. Ed.<\/em> 2021<\/strong>, 60<\/em>, 8874\u20138881.. DOI: 10.1002\/anie.202015232 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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100.<\/strong> Swain, M.; Sadykhov, G.; Wang, R.; Kwon, O. Dealkenylative Alkenylation: Formal \u03c3\u2010Bond Metathesis of Olefins. Angew. Chem. Int. Ed.<\/em> 2020<\/strong>, 59<\/em>, 17565\u201317571. DOI: 10.1002\/anie.202005267 [abstract<\/a>] [pdf<\/a>]
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99.<\/strong> Blank, B.; Andrews, I.; Kwon, O. Phosphine-Catalyzed (4 + 1) Annulation: Rearrangement of Allenylic Carbamates to 3-Pyrrolines Through Phosphonium Diene Intermediates. ChemCatChem.<\/em> 2020<\/strong>, 12<\/em>, 4352\u20134372. DOI: 10.1002\/cctc.202000626 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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98.<\/strong> Wilting, F.; Kopp, R.; Gurnev, P. A.; Schedel, A.; Dupper, N. J.; Kwon, O.; Nicke, A.; Gudermann, T.; Schredelseker, J. The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake. Br. J. Pharmacol.<\/em> 2020<\/strong>, 177<\/em>, 2947\u20132958. DOI: 10.1111\/bph.15022 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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97.<\/strong> Smaligo, A. J.; Wu, J.; Burton, N. R.; Hacker, A. S.; Shaikh, A. C.; Quintana, J. C.; Wang, R.; Xie, C.; Kwon, O. Oxodealkenylative cleavage of alkene C(sp3<\/sup>)\u2013C(sp\u00b2) bonds: A practical method for introducing carbonyls into chiral pool materials. Angew. Chem. Int. Ed.<\/em> 2020<\/strong>, 59<\/em>, 1211\u20131215. DOI: 10.1002\/anie.20191320 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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96.<\/strong> Smaligo, A. J.; Kwon, O. Dealkenylative thiylation of C(sp3<\/sup>)\u2013C(sp\u00b2) bonds. Org. Lett.<\/em> 2019<\/strong>, 21<\/em>, 8592\u20138597. DOI: 10.1021\/acs.orglett.9b03186 [abstract<\/a>] [pdf<\/a>]
On the Organic Letters “Most Read” list for the month of November.
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95.<\/strong> Shaikh, A. C.; Kwon, O. Discussion Addendum for: Phosphine-Catalyzed [3 + 2] Annulation: Synthesis of Ethyl 5-(tert-Butyl)-2-phenyl-1-tosyl-3-pyrroline-3-carboxylate. Org. Synth.<\/em> 2019<\/strong>, 96<\/em>, 214\u2013231. DOI: 10.15227\/orgsyn.096.0214 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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94.<\/strong> Zhang, K.; Cai, L.; Hong, S.; Kwon, O. Phosphine-Catalyzed \u03b1<\/em>-Umpolung\u2013Aldol Reaction for the Synthesis of Benzo[b<\/em>]azapin-3-ones. Org. Lett.<\/em> 2019<\/strong>, 21<\/em>, 5143\u20135146. DOI: 10.1021\/acs.orglett.9b01749 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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93.<\/strong> Cai, L.; Zhang, K.; Chen, S.; Lepage, R. J.; Houk, K. N.; Krenske, E. H.; Kwon, O. Catalytic asymmetric Staudinger\u2013aza-Wittig reaction for the synthesis of heterocyclic amines. J. Am. Chem. Soc.<\/em> 2019<\/strong>, 141<\/em>, 9537\u20139542. DOI: 10.1021\/jacs.9b04803 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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92.<\/strong> Smaligo, A. J.; Swain, M.; Quintana, J. C.; Tan, M. F.; Kim, D. A.; Kwon, O. Hydrodealkenylative C(sp3<\/sup>)\u2013C(sp\u00b2) bond fragmentation. Science<\/em> 2019<\/strong>, 364<\/em>, 681\u2013685. DOI: 10.1126\/science.aaw4212 [abstract<\/a>] [pdf<\/a>]
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91.<\/strong> Shaikh, A. C.; Kwon, O. Discussion Addendum for: Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Ethyl 6-Phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. Org. Synth.<\/em> 2019<\/strong>, 96<\/em>, 110\u2013123. DOI: 10.15227\/orgsyn.096.0110 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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90.<\/strong> Khong, S.; Xie, C.; Wang, X.; Tan, H.; Kwon, O. Chiral Aminophosphines Derived from Hydroxyproline and Their Application in Allene\u2013Imine [4 + 2] Annulation. J. Antibiot.<\/em> 2019<\/strong>, 72<\/em>, 389\u2013396. DOI: 10.1038\/s41429-019-0181-0. [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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89.<\/strong> Liu, H.; Lin, Y.; Zhao, Y.; Xiao, M.; Zhou, L.; Wang, Q.; Zhang, C.; Wang, D.; Kwon, O.; Guo, H. Phosphine-Promoted [4+3] Annulation of Allenoate with Aziridines for Synthesis of Tetrahydroazepines: Phosphine-Dependent [3+3] and [4+3] Pathways. RSC Adv.<\/em> 2019<\/strong>, 9<\/em>, 1214\u20131221. DOI: 10.1039\/C8RA09852B [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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88.<\/strong> Kearney, S. E., et al<\/em>. Canvas: a crowd-sourced, natural product screening library for exploring biological space. ACS Cent. Sci.<\/em> 2018<\/strong>, 4 <\/em>, 1727\u20131741. DOI: 10.1021\/acscentsci.8b00747 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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87.<\/strong> Guo, H.; Fan, Y. C.; Sun, Z.; Wu, Y.; Kwon, O. Phosphine Organocatalysis. Chem. Rev.<\/em> 2018<\/strong>, 118<\/em>, 10049\u201310293. DOI: 10.1021\/acs.chemrev.8b00081 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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86.<\/strong> Xu, Q.; Dupper, N. J.; Smaligo, A. J.; Fan, Y. C.; Cai, L.; Wang, Z.; Langenbacher, A. D.; Chen, J.; Kwon, O. Catalytic Enantioselective Synthesis of Guvacine Derivatives through [4 + 2] Annulations of Imines with \u03b1<\/em>-Methylallenoates. Org. Lett.<\/em> 2018<\/strong>, 20<\/em>, 6089\u20136093. DOI: 10.1021\/acs.orglett.8b02489 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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85.<\/strong> Lee, C. J.; Swain, M.; Kwon, O. “Synthesis of Cyclic \u03b2-Silylalkenyl Triflates via an Alkenyl Cation Intermediate” Org. Lett.<\/em> 2018<\/strong>, 20<\/em>, 5474\u20135477. DOI: 10.1021\/acs.orglett.8b02398 [abstract<\/a>] [pdf<\/a>]
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84.<\/strong> Smaligo, A. J.; Vardhineedi, S.; Kwon, O. Carvone-Derived P-Stereogenic Phosphines: Design, Synthesis, and Use in Allene\u2013Imine [3 + 2] Annulation. ACS Catal.<\/em> 2018<\/strong>, 8<\/em>, 5188\u20135192. DOI: 10.1021\/acscatal.8b01081 [abstract<\/a>] [pdf<\/a>]
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83.<\/strong> Zhang, K.; Cai, L.; Yang, Z.; Houk, K. N.; Kwon, O. Bridged [2.2.1] Bicyclic Phosphine Oxide Facilitates Catalytic \u03b3-umpolung\u2013Wittig Olefination. Chem. Sci.<\/em> 2018<\/strong>, 9<\/em>, 1867\u20131872. DOI: 10.1039\/C7SC04381C [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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82.<\/strong> Zhao, J.; Brosmer, J. L.; Tang, Q.; Yang, Z.; Houk, K. N.; Diaconescu, P. L.; Kwon, O. Intramolecular Crossed [2 + 2] Photocycloaddition by Visible Light-Induced Energy Transfer. J. Am. Chem. Soc.<\/em> 2017<\/strong>, 139<\/em>, 9807\u20139810. DOI: 10.1021\/jacs.7b05277 [abstract<\/a>] [pdf<\/a>]
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81.<\/strong> Schweitzer, M. K.; Wilting, F.; Sedej, S.; Dreizehnter, L.; Dupper, N. J.; Moretti, A.; My, I.; Kwon, O.; Priori, S. G.; Laugwitz, K.-L.; Breit, A.; Schnitzler, M. M.; Gudermann, T.; Schredelseker, J. Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models. J. Am. Coll. Cardiol. Basic Trans. Science.<\/em> 2017<\/strong>, 2<\/em>, 737\u2013747 . DOI: 10.1016\/j.jacbts.2017.06.008 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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80. <\/strong>Fern\u00e1ndez-del-R\u00edo, L.; Nag, A.; Casado, E. G.; Ariza, J.; Awad, A. M.; Joseph A. I.; Kwon, O.; Verdin, E..; de Cabo, R.; Schneider, C.; Torres, J. Z.; Bur\u00f3n, M. I.; Clarke, C. F.; Villalba, J. M. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free Radical Bio. Med.<\/em> 2017<\/strong>, 110<\/em>, 176\u2013187. DOI: 10.1016\/j.freeradbiomed.2017.06.006 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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79.<\/strong> Zhang, K.; Kwon, O. 2-[(4-Methylphenyl)sulfonyl]-5-phenyl-2-aza-5-phosphabicyclo[2.2.1.]heptane. In Encyclopedia of reagents for Organic Synthesis [Online]<\/em>, John Wiley & Sons Ltd., 2017. DOI: 10.1002\/047084289X.rn02004.  [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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78.<\/strong> Koc, E.; Kwon, O. Total Syntheses of Heliotridane and Pseudoheliotridane through the 6 Electrocyclization of Nitrodienes. \u2018Symposium-in-Print: New Advances in Pericyclic Reactions\u2019 Tetrahedron<\/em> 2017<\/strong>, 73<\/em>, 4195\u20134200. DOI: 10.1016\/j.tet.2016.12.056 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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77.<\/strong> Fan, Y. C.; Kwon, O. Beyond the Morita\u2013Baylis\u2013Hillman Reaction (n \u2192 \u03c0*). In Lewis Base Catalysis<\/em>, Vol. 2; Vedejs E. Denmark, S. E., Eds.; Wiley-VCH Verlag GmbH & Co, KGaA, Boschstr: Weinheim, Germany, 2016; pp 715\u2013804. DOI: 10.1002\/9783527675142.ch15 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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76.<\/strong> Kibbie, J. J.; Teles, R. M. B.; Wang, Z.; Hong, P.; Montoya, D.; Krutzik, S.; Lee, S.; Kwon, O.; Modlin, R. L.; Cruz, D. Jagged1 Instructs Macrophage Differentiation in Leprosy. PloS Pathog.<\/em> 2016<\/strong>, 12<\/em>, e1005808. DOI: 10.1371\/journal.ppat.1005808 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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75.<\/strong> Zhou, Q.-F.; Zhang, K.; Cai, L.; Kwon, O. Phosphine-Catalyzed Intramolecular Cyclization of \u03b1-(\u03b2-Nitroethyl)allenoates to Form (Z)-Furanone Oximes. Org. Lett.<\/em> 2016<\/strong>, 18<\/em>, 2954\u20132957.  [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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74.<\/strong> Cai, L.; Zhang, K.; Kwon, O. Catalytic Asymmetric Total Synthesis of (\u2013)-Actinophyllic Acid. J. Am. Chem. Soc.<\/em> 2016<\/strong>, 138<\/em>, 3298\u20133301. DOI: 10.1021\/jacs.6b00567 [abstract<\/a>] [pdf<\/a>]
organic-chemistry.org highlight [link<\/a>]<\/p>\n\n\n\n

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73.<\/strong> Xiao, Y.; Guo, H.; Kwon, O. Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Enantioselective Intermolecular Cyclization Reactions. Aldrichimica Acta<\/em>, 2016<\/strong>, 49<\/em>, 3\u201313. [pdf<\/a>]<\/p>\n\n\n\n

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72.<\/strong> Wang; Z.; Xu, X.; Gu, Z.; Feng, W.; Qian, H.; Li, Z.; Kwon, O. Interrupted Nazarov Cyclization of 1,4-Pentadien-3-ols: Preparation of Cyclopenta[b]indoles. Chem. Commun.<\/em> 2016<\/strong>, 52<\/em>, 2811\u20132814. DOI: 10.1039\/C5CC08596A [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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71.<\/strong> Lu, J.; Yoshimura, K.; Goto, K.; Lee, C.; Hamura, K.; Kwon, O.; Tamanoi, F. Nanoformulation of geranylgeranyltransferase-I inhibitors for cancer therapy: Liposomal encapsulation and pH-dependent delivery to cancer cells. PloS ONE<\/em>, 2015<\/strong>, 10<\/em>, e346b403. DOI: 10.1371\/journal.pone.0137595 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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70.<\/strong> Zhang, K.; Cai, L.; Jiang, X.; Garcia-Garibay, M. A.; Kwon, O. Phosphine-Mediated Iterative Arene Homologation Using Allenes. J. Am. Chem. Soc.<\/em> 2015<\/strong>, 137<\/em>, 11258\u201311261. DOI: 10.1021\/jacs.5b07403 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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69. <\/strong>Fan, Y. C.; Kwon, O. Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine-Palladium Catalysis. Org. Lett.<\/em> 2015<\/strong>, 17<\/em>, 2058\u20132061. DOI: 10.1021\/acs.orglett.5b00554 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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68.<\/strong> Xie, L. X.; Williams, K.; He, C. H.; Weng, E.; Khong, S.; Rose, T.; Kwon, O.; Bensinger, S.; Marbois, B.; Clarke, C. F. Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis. J. Lipid Res.<\/em> 2015<\/strong>, 56<\/em>, 909\u2013919. DOI: 10.1194\/jlr.M057919 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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67.<\/strong> Wang, Z.; Kwon, O. (S)- 4,5-Dihydro-3H-dinaphtho[2,1-c:1′,2′-e]azepine. In Encyclopedia of reagents for Organic Synthesis<\/em>, John Wiley & Sons Ltd., 2015. DOI: 10.1002\/047084289X.rn01773 [pdf<\/a>]<\/p>\n\n\n\n

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66.<\/strong> Dupper, N. J.; Kwon, O. Functionalized \u03b1,\u03b1-Dibromoesters Through Claisen Rearrangements of Dibromoketene Acetals. Org. Lett.<\/em> 2015<\/strong>, 17<\/em>, 1054\u20131057. DOI: 10.1021\/acs.orglett.5b00209 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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65.<\/strong> Chang, J. W.; Zuhl, A. M.; Speers, A. E.; Niessen, S.; Brown, S. J.; Mulvihill, M. M.; Spicer, T. P.; Southern, M.; Scampavia, L.; Fernandez-Vega, V.; Ferguson, J.; Dix, M. M.; Hodder, P. S.; Rosen, H.; Nomura, D. K.; Kwon, O.; Hsu, K.-L.; Cravatt, B. F. A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem. Biol. <\/em>2015<\/strong>, 10<\/em>, 925\u2013932. DOI: 10.1021\/cb500893q [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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64.<\/strong> Zhou, Q.-F.; Zhang, K.; Kwon, O. Stereoselective Synthesis of \u03b1,\u03b2-Unsaturated \u03b3-Amino Esters Through Phosphine-Catalyzed \u03b3\u03b3-Umpolung Addition of Sulfonamides to \u03b3-Substituted Allenoates. Tetr. Lett.<\/em> 2015<\/strong>, 56<\/em>, 3273\u20133276. DOI: 10.1016\/j.tetlet.2015.01.120 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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63.<\/strong> Shimizu, H.; Schredelseker, J.; Huang, J.; Lu, K.; Naghdi, S.; Lu, F.; Franklin, S.; Fiji, H. D. G.; Wang, K.; Zhu, H.; Tian, C.; Lin, B.; Nakano, H.; Ehrlich, A.; Nakai, J.; Stieg, A. Z.; Gimzewski, J. K.; Nakano, A.; Goldhaber, J. I.; Vondriska, T. M.; Hajnoczky, G.; Kwon, O.; Chen, J.-N. Mitochondrial Ca2+<\/sup> uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. eLife<\/em> 2015<\/strong>, 4<\/em>, e04801. DOI: 10.7554\/eLife.04801 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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62.<\/strong> Henry, C. E.; Xu, Q.; Fan, Y. C.; Martin, T. J.; Belding, L.; Dudding, T.; Kwon, O. Hydroxyproline-derived Pseudo-enantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (-)-Pyrrolines. J. Am. Chem. Soc. <\/em>2014<\/strong>, 136<\/em>, 11890\u201311893. DOI: 10.1021\/ja505592h [abstract<\/a>] [pdf<\/a>]
SYNFACTS<\/em> 2014<\/strong>, 10<\/em>, 1214. highlight [link<\/a>]
Kwon Group – Professor Product Portal (Sigma Aldrich) [link<\/a>]<\/p>\n\n\n\n

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61.<\/strong> Xiao, Y.; Sun, Z.; Guo, H.; Kwon, O. Chiral phosphines in nucleophilic organocatalysis. Beilstein J. Org. Chem.<\/em>, 2014<\/strong>, 10<\/em>, 2089\u20132121. DOI: 10.3762\/bjoc.10.218 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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60.<\/strong> Khong, S. N.; Kwon, O. Phosphine-Initiated General Base-Catalyzed Quinolone Synthesis. Asian J. Org. Chem.<\/em>, 2014<\/strong>, 3<\/em>, 453\u2013457. DOI: 10.1002\/ajoc.201402039 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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59.<\/strong> Wang, Z.; Xu, X.; Kwon, O. Phosphine Catalysis of Allenes with Electrophiles. Chem. Soc. Rev., Special Issue “Progress in Allene Chemistry<\/em>” 2014<\/strong>, 43<\/em>, 2927\u20132940. DOI: 10.1039\/C4CS00054D [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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58. <\/strong>Fan, Y. C.; Kwon, O. Advances in Nucleophilic Phosphine Catalysis of Alkenes, Allenes, Acetylenes, and MBHADs. Chem. Commun.<\/em> 2013<\/strong>, 49<\/em>, 11588\u201311619. DOI: 10.1039\/C3CC47368F [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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57.<\/strong> Zimonjic, D. B.; Chan, L. N.; Tripathi, V.; Lu, J.; Kwon, O.; Popescu, N. C.; Lowy, D. R.; Tamanoi, F. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. BMC Cancer<\/em>, 2013<\/strong>, 13<\/em>, 198. DOI:10.1186\/1471-2407-13-198.[abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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56.<\/strong> Creech, G. S.; Kwon, O. Palladium-catalyzed coupling of electron deficient \u03b2-nitrovinyl and o<\/em>-nitroaryl thioethers for the synthesis of nitrodienes, nitrostyrenes and nitrobiaryls. Chem. Sci. <\/em>2013<\/strong>, 4<\/em>, 2670\u20132674. DOI: 10.1039\/C3SC50773D [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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55.<\/strong> Wang, Z.; Kwon, O. Phosphine Organocatalysis as a Platform for Diversity-Oriented Synthesis. In Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology<\/em> Trabocchi, A., Ed.; John Wiley & Sons, Inc., 2013; pp 97-133. DOI: 10.1002\/9781118618110.ch4 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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54.<\/strong> Patel, A.; Barcan, G. A.; Kwon, O.; Houk, K. N. Origins of 1,6-Stereoinduction in Torquoselective 6\u03c0 Electrocyclizations. J. Am. Chem. Soc.<\/em> 2013<\/strong>, 135<\/em>, 4878\u20134883. DOI: 10.1021\/ja400882y [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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53.<\/strong> Florian, A. E.; Lepensky, C. K.; Kwon, O.; Haynes, M. K.; Sklar, L. A.; Zweifach, A. Flow Cytometry Enables A High-throughput Homogeneous Fluorescent Antibody-Binding Assay for -Cytotoxic T Cell Lytic Granule Exocytosis. J. Biomol. Screen. <\/em>2013<\/strong>, 18<\/em>, 420\u2013429. DOI: 10.1177\/1087057112466697 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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52.<\/strong> Barcan, G. A.; Patel, A.; Houk, K. N.; Kwon, O. A Torquoselective 6\u03c0 Electrocyclization Approach to Reserpine Alkaloids. Org. Lett.<\/em> 2012<\/strong>, 14<\/em>, 5388\u20135391. DOI: 10.1021\/ol302265z [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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51.<\/strong> Khong, S. N.; Kwon, O. One-Pot Phosphine-Catalyzed Quinoline Synthesis. J. Org. Chem. <\/em>2012<\/strong>, 77<\/em>, 8257\u20138267. DOI: 10.1021\/jo30 15825 [abstract<\/a>] [pdf<\/a>]
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50.<\/strong> Villa, R. A.; Xu, Q.; Kwon, O. Total Synthesis of (\u00b1)-Hirsutine: The Application of Phosphine-Catalyzed [4+2] Annulation of Imine with \u03b1-Methyl Allenoate. Org. Lett.<\/em> 2012<\/strong>, 14<\/em>, 4634\u20134637. DOI: 10.1021\/ol302077n [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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49.<\/strong> Fan, Y. C.; Kwon, O. Phosphine\/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3- Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol. Org. Lett.<\/em> 2012<\/strong>, 14<\/em>, 3264\u20133267. DOI: 10.1021\/ol301154f [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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48.<\/strong> Andrews, I. P.; Kwon, O. Enantioselective total synthesis of (+)-ibophyllidine via an asymmetric phosphine-catalyzed [3+2] annulation. Chem. Sci.<\/em> 2012<\/strong>, 3<\/em>, 2510\u20132514. DOI: 10.1039\/C2SC20468A [abstract<\/a>] [pdf<\/a>]
Listed in the “Top ten most accessed articles in May 2012” [link<\/a>]
Listed in the “Top ten most accessed articles in June 2012” [link<\/a>]
SYNFACTS<\/em>, 2012<\/strong>, 8<\/em>, 1284. highlight [link<\/a>]
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47.<\/strong> Khong, S. N.; Kwon, O. Chiral Aminophosphine Syntheses and Initial Attempts in Enantioselective Double-Michael Indoline Synthesis. Molecules, Special Issue “Asymmetric Catalysis,”<\/em> 2012<\/strong>, 17<\/em>, 5626\u20135650. DOI: 10.3390\/molecules17055626 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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46.<\/strong> Andrews, I. P.; Blank, B. R.; Kwon, O. Phosphine-catalyzed intramolecular \u03b3-umpolung addition of \u03b1-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3 pyrrolines. Chem. Commun.<\/em> 2012<\/strong>, 48<\/em>, 5373\u20135375. DOI: 10.1039\/C2CC31347B [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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45.<\/strong> Jing, C.; Na, R.; Liu, H.; Zhang, L.; Liu, J.; Wang, M.; Zhong, J.; Kwon, O.; Guo, H. Phosphine-Catalyzed [3+2] and [4+3] Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates. Adv. Syn. Catal.<\/em> 2012<\/strong>, 354<\/em>, 1023\u20131034. DOI: 10.1002\/adsc.201100831 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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44.<\/strong> Xu, Q.; Kwon, O. Bis(diphenylphsophino)methane. In Encyclopedia of reagents for Organic Synthesis [Online]<\/em>, John Wiley & Sons Ltd., 2012. DOI: 10.1002\/047084289X.rn01439 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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43.<\/strong> Fan, Y. C.; Kwon, O. Phosphine Catalysis. In Science of Synthesis<\/em>; List, B., Ed.; Asymmetric Organocatalysis, Vol. 1, Lewis Base and Acid Catalysts; Georg Thieme: Stuttggart, 2012; pp 723-782. DOI: 10.1055\/sos-SD-204-00359. [abstract<\/a>]<\/p>\n\n\n\n

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42.<\/strong> Chan, L. N.; Watanabe, M.; Kwon, O.; Tamanoi, F. Small molecule inhibitors of GGTase-I from the heterocycle library derived from phosphine catalysis. In Enzymes<\/em>; Hrycyna, C.; Bergo, M.; Tamanoi, F., Eds.; Volume 30, Protein Prenylation Part B; Academic Press\/Elsevier: Amsterdam, 2011; pp 165-177. DOI: 10.1016\/B978-0-12-415922-8.00007-0 [abstract<\/a>]<\/p>\n\n\n\n

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41. <\/strong> Chan, L. N.; Fiji, H. D. G.; Watanabe, M.; Kwon, O.; Tamanoi, F. .Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I. PloS ONE<\/em>, 2011<\/strong>, 6<\/em>, e26135. DOI: 10.1371\/journal.pone.0026135 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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40.<\/strong> Szeto, J.; Sriramurthy, V.; Kwon, O. Phosphine-Initiated General Base Catalysis: Facile Access to Benzannulated 1,3-Diheteroatom Five-Membered Rings via Double-Michael Reactions of Allenes. Org. Lett.<\/em> 2011<\/strong>, 13<\/em>, 5420\u20135423. DOI: 10.1021\/ol201730q [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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39.<\/strong> Na, R.; Jing, C.; Xu, Q.; Shi, J.; Jiang, H.; Wu, X.; Zhong, J.; Wang, M.; Benitez, D.; Goddard, W. A.; Guo, H.; Kwon, O. Phosphine-Catalyzed Annulation Reactions of Azomethine Imines: Allene-Dependent [3+2], [3+3], [4+3], and [3+2+3] Pathways. J. Am. Chem. Soc.<\/em> 2011<\/strong>, 133<\/em>, 13337\u201313348. DOI: 10.1021\/ja200231v [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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38.<\/strong> Tran, Y. S.; Martin, T. J.; Kwon, O. Phosphine-Catalyzed [4 + 2] Annulations of 2-Alkylallenoates and Olefins: Synthesis of Multisubstituted Cyclohexenes. Chem. Asian. J.<\/em> 2011<\/strong>, 6<\/em>, 2101\u20132106. DOI: 10.1002\/asia.201100190 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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37.<\/strong> Fan, Y. C.; Kwon, O. Diversity-Oriented Synthesis Based on the DPPP-Catalyzed Mixed Double-Michael Reactions of Electron-Deficient Acetylenes and \u03b2-Amino Alcohols. Molecules, Special Issue “Diversity-Oriented Synthesis”<\/em> 2011<\/strong>, 16<\/em>, 3802\u20133825. DOI: 10.3390\/molecules16053802 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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36.<\/strong> Martin, T. J.; Tran, Y. S; Vakhshori, V. G.; Kwon, O. Phosphine-Catalyzed \u03b2’-Umpolung Addition of Activated \u03b1-Alkyl Allenes. Org. Lett.<\/em> 2011<\/strong>, 13<\/em>, 2586\u20132589. DOI: 10.1021\/ol200697m [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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35.<\/strong> Cruz, D.; Wang, Z.; Kibbie, J.; Modlin, R.; Kwon, O. Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven innate immunity. Proc. Natl. Acad. Sci. U. S. A.<\/em> 2011<\/strong>, 108<\/em>, 6769\u20136774. DOI: 10.1073\/pnas.1015254108 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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34.<\/strong> Choi, J.; Mouillesseauex, K.; Wang, Z.; Fiji, H. D. G.; Kinderman, S. S.; Otto, G. W.; Geisler, R.; Kwon, O.; Chen, J.-N. Aplexone Targets the HMG-CoA Reductase Pathway and Differentially Regulates Arteriovenous Angiogenesis. Development<\/em> 2011<\/strong>, 138<\/em>, 1173\u20131182. DOI: 10.1242\/dev.054049 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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33.<\/strong> Andrews, I. P.; Kwon, O. Phosphine Catalyzed [3+2] Annulation: Synthesis of Ethyl 5-(tert-Butyl)-2-phenyl-1-Tosyl-3-Pyrroline-3-Carboxylate. Org. Synth.<\/em> 2011<\/strong>, 88<\/em>, 138\u2013151. DOI: 10.1002\/0471264229.os088.13 [abstract<\/a>] [pdf<\/a>]<\/p>\n\n\n\n

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32.<\/strong> Wang, Z.; Castellano, S.; Kinderman, S. S.; Argueta, C. E.; Beshir, A. B.; Fenteany, G.; Kwon, O. Diversity via a Branched Reaction Pathway: Generation of A Library of Sixteen Muticyclic Scaffolds and Identification of Anti-Migratory Agents. Chem. Eur. J.<\/em> 2011<\/strong>, 17<\/em>, 649\u2013654.  DOI: 10.1002\/chem.201002195 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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31.<\/strong> Creech, G. S.; Kwon, O. Tandem 6?-Electrocyclization and Cycloaddition of Nitrodienes to Yield Multicyclic Nitroso Acetals. J. Am. Chem. Soc.<\/em> 2010<\/strong>, 132<\/em>, 8876\u20138877. DOI: 10.1021\/ja1038819 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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30.<\/strong> Khong, S. N.; Tran, Y. S.; Kwon, O. Equilibrium Between a Vinylogous Ylide and a Phosphonium Dienolate Zwitterion: Vinylogous Wittig Olefination Versus Vinylogous Aldol-Type Reaction. Tetrahedron<\/em> 2010<\/strong>, 66<\/em>, 4760\u20134768. DOI: 10.1016\/j.tet.2010.03.044 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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29.<\/strong> Vardhineedi, S.; Kwon, O. Diphosphine-Catalyzed Mixed Double-Michael Reaction: A Unified Synthesis of Indolines, Dihydropyrrolopyridines, Benzimidazolines, Tetrahydroquinolines, Tetrahydroisoquinolines, Dihydrobenzo-1,4-oxazines, and Dihydrobenzo-3,1-oxazines. Org. Lett. <\/em>2010<\/strong>, 12<\/em>, 1084\u20131087. DOI: 10.1021\/ol100078w [abstract<\/a>] [pdf]<\/a>
SYNFACTS<\/em>, 2010<\/strong>, 476<\/em> highlight [link<\/a>]<\/p>\n\n\n\n

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28.<\/strong> Guo, H.; Xu, Q.; Kwon, O. Phosphine-Promoted [3+3] Annulation of Aziridines with Allenoates: A Facile Entry into Highly Functionalized Tetrahydropyridines. J. Am. Chem. Soc.<\/em> 2009<\/strong>, 131<\/em>, 6318\u20136319. DOI: 10.1021\/ja8097349 [abstract<\/a>] [pdf]<\/a>
SYNFACTS<\/em>, 2009<\/strong>, 7<\/em>, 0748 highlight [link<\/a>]<\/p>\n\n\n\n

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27.<\/strong> Lu, J.; Chan, L.; Fiji, H. D. G.; Dahl, R.; Kwon, O.; Tamanoi, F. In vivo anticancer effect of a novel inhibitor of protein geranylgeranyltransferase I. Mol. Cancer Ther. <\/em>2009<\/strong>, 8<\/em>, 1218\u20131226. DOI: 10.1158\/1535-7163.MCT-08-1122 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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26.<\/strong> Lu, K.; Kwon, O. Phosphine-catalyzed [4+2] Annulation: Synthesis of Ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. Org. Synth.<\/em> 2009<\/strong>, 86<\/em>, 212\u2013224. DOI: 10.15227\/orgsyn.086.0212 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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25.<\/strong> Andrews, I. P.; Kwon, O. Highly Efficient Palladium-Catalyzed Hydrostannation of Ethyl Ethynyl Ether. Tetrahedron Lett.<\/em> 2008<\/strong>, 49<\/em>, 7097\u20137099. DOI: 10.1016\/j.tetlet.2008.09.147 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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24.<\/strong> Creech, G. S.; Zhu, X.; Fonovic, B.; Travis, D.; Kwon, O. Theory-Guided Design of Bronsted Acid-Assisted Phosphine Catalysis: Synthesis of Dihydropyrones from Aldehydes and Allenoates. Tetrahedron<\/em> 2008<\/strong>, 64<\/em>, 6935\u20136942. DOI: 10.1016\/j.tet.2008.04.075 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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23.<\/strong> Watanabe, M.; Fiji, H. D. G.; Guo, L.; Chan, L.; Kinderman, S. S.; Slamon, D. J.; Kwon, O.; Tamanoi, F. Inhibitors of protein geranylgeranyltransferase-I and rab geranylgeranyltransferase identified from a library of allenoate derived compounds. J. Biol. Chem.<\/em> 2008<\/strong>, 283<\/em>, 9571\u20139579. DOI: 10.1074\/jbc.M706229200 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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22.<\/strong> Creech, G. S.; Kwon, O. Alcohol-Assisted Phosphine Catalysis: One-Step Syntheses of Dihydropyrones from Aldehydes and Allenoates. Org. Lett. <\/em>2008<\/strong>, 10<\/em>, 429\u2013432. DOI: 10.1021\/ol702462w [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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21.<\/strong> Tran, Y. S.; Kwon, O. Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Cyclohexenes. J. Am. Chem. Soc.<\/em> 2007<\/strong>, 129<\/em>, 12632\u201312633. DOI: 10.1021\/ja0752181 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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20.<\/strong> Sriramurthy, V.; Barcan, G. A.; Kwon, O. Bisphosphine-Catalyzed Mixed Double-Michael Reactions:  Asymmetric Synthesis of Oxazolidines, Thiazolidines, and Pyrrolidines. J. Am. Chem. Soc.<\/em> 2007<\/strong>, 129<\/em>, 12928\u201312929. DOI: 10.1021\/ja073754n [abstract<\/a>] [pdf]<\/a>
organic-chemistry.org highlight [link<\/a>]<\/p>\n\n\n\n

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19.<\/strong> Henry, C. E.; Kwon, O. Phosphine-Catalyzed Synthesis of Highly Functionalized Coumarins. Org. Lett.<\/em> 2007<\/strong>, 9<\/em>, 3069\u20133072. DOI: 10.1021\/ol071181d [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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18.<\/strong> Zhu, X.-F.; Henry, C. E.; Kwon, O. Stable Tetravalent Phosphonium Enolate Zwitterions. J. Am. Chem. Soc.<\/em> 2007<\/strong>, 129<\/em>, 6722\u20136723. DOI: 10.1021\/ja071990s [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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17.<\/strong> Castellano, S.; Fiji, H. D. G.; Kinderman, S. S.; Watanabe, M.; De Leon, P.; Tamanoi, F.; Kwon, O. Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I. J. Am. Chem. Soc.<\/em> 2007<\/strong>, 129<\/em>, 5843\u20135845. DOI: 10.1021\/ja070274n [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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16.<\/strong> Mercier, E.; Fonovic, B.; Henry, C.; Kwon, O.; Dudding, T. Phosphine Triggered [3+2] Allenoate-Acrylate Annulation: A Mechanistic Enlightenment. Tetrahedron Lett.<\/em> 2007<\/strong>, 48<\/em>, 3617\u20133620. DOI: 10.1016\/j.tetlet.2007.03.030 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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15.<\/strong> Dudding, T.; Kwon, O.; Mercier, E. .Theoretical Rationale for Regioselection in Phosphine Catalyzed Allenoate Additions to Acrylates, Imines and Aldehydes. Org. Lett.<\/em> 2006<\/strong>, 8<\/em>, 3643\u20133646. DOI: 10.1021\/ol061095y [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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14. <\/strong>Tran, Y. S.; Kwon, O. An Application of the Phosphine-Catalyzed [4 + 2] Annulation in Indole Alkaloid Synthesis: Formal Syntheses of (\u00b1)-Alstonerine and (\u00b1)-Macroline. Org. Lett. <\/em>2005<\/strong>, 7<\/em>, 4289\u20134291. DOI: 10.1021\/ol051799s [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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13.<\/strong> Zhu, X.; Schaffner, A.; Li, R. C.; Kwon, O. Phosphine-Catalyzed Synthesis of 6-Substituted 2-Pyrones: Manifestation of E\/Z-Isomerism in the Zwitterionic Intermediate. Org. Lett.<\/em> 2005<\/strong>, 7<\/em>, 2977\u20132980. DOI: 10.1021\/ol050946j [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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12.<\/strong> Zhu, X.; Henry, C. E.; Wang, J.; Dudding, T.; Kwon, O. A Phosphine-Catalyzed Synthesis of 1,3-Dioxan-4-ylidenes. Org. Lett.<\/em> 2005<\/strong>, 7<\/em>, 1387\u20131390. DOI: 10.1021\/ol050203y [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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11.<\/strong> Zhu, X.; Henry, C. E.; Kwon, O. A highly diastereoselective synthesis of 3-carbethoxy-2,5-disubstituted-3-pyrrolines by phosphine catalysis. Tetrahedron<\/em> 2005<\/strong>, 61<\/em>, 6276\u20136282. DOI: 10.1016\/j.tet.2005.03.104 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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10.<\/strong> Du, X.; Chu, H. V.; Kwon, O. A concise synthesis of the functionalized [5-7-6] tricyclic skeleton of guanacastepene A. Tetrahedron Lett.<\/em> 2004<\/strong>, 45<\/em>, 8843\u20138846. DOI: 10.1016\/j.tetlet.2004.09.187 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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9.<\/strong> Du, X.; Chu, H. V.; Kwon, O. Synthesis of the [5-7-6] Tricyclic Core of Guanacastepene A via an Intramolecular Mukaiyama Aldol Reaction. Org. Lett.<\/em> 2003<\/strong>, 5<\/em>, 1923\u20131926. DOI: 10.1021\/ol0344873 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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8.<\/strong> Zhu, X.; Lan, J.; Kwon, O. An Expedient Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Highly Functionalized Tetrahydropyridines. J. Am. Chem. Soc.<\/em> 2003<\/strong>, 125<\/em>, 4716\u20134717. DOI: 10.1021\/ja0344009 [abstract<\/a>] [pdf]<\/a>
organic-chemistry.org highlight [link<\/a>]<\/p>\n\n\n\n

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Post-doctoral Work <\/span><\/p>\n\n\n\n

7.<\/strong> Schmidt, D. R.; Kwon, O.; Schreiber, S. L. Macrolactones in Diversity-Oriented Synthesis: Preparation of a Pilot Library and an Exploration of Factors Controlling Macrocyclization. J. Comb. Chem.<\/em> 2004<\/strong>, 6<\/em>, 286\u2013292. DOI: 10.1021\/cc020076m [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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6.<\/strong> Kwon, O.; Park, S. B.; Schreiber, S. L. Skeletal Diversity via a Branched Pathway: Efficient Synthesis of 29,400 Discrete, Polycyclic Compounds and Their Arraying into Stock Solutions. J. Am. Chem. Soc.<\/em> 2002<\/strong>, 124<\/em>, 13402\u201313404. DOI: 10.1021\/ja028086e [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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Graduate Work <\/span><\/p>\n\n\n\n

5.<\/strong> Kwon, O.; Su, D.; Meng, D.; Deng, W.; D. Amico, D. C.; Danishefsky, S. J. A Stereospecific Geminal Alkylation Scheme En Route To CP-225,917 and CP-263,114. Angew. Chem., Int. Ed. <\/em>1998<\/strong>, 37<\/em>, 1880\u20131882. DOI: 10.1002\/(SICI)1521-3773(19980803)37:13\/14<1880::AID-ANIE1880>3.0.CO;2-5 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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4.<\/strong> Kwon, O.; Su, D.; Meng, D.; Deng, W.; D?Amico, D. C.; Danishefsky, S. J. Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure By Sequential Aldol Condensation and Intramolecular Heck Ring Closure. Angew. Chem., Int. Ed.<\/em> 1998<\/strong>, 37<\/em>, 1877\u20131880. DOI: 10.1002\/(SICI)1521-3773(19980803)37:13\/14<1877::AID-ANIE1877>3.0.CO;2-2 [abstract<\/a>] [pdf<\/a>]<\/a><\/p>\n\n\n\n

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3.<\/strong> Kwon, O.; Danishefsky, S. J. Synthesis of Asialo GM1. New Insights in the Application of Sulfonamidoglycosidation in Oligosaccharide Assembly: Subtle Proximity Effects in the Stereochemical Governance of Glycosidation. J. Am. Chem. Soc. <\/em>1998<\/strong>, 120<\/em>, 1588\u20131599. DOI: 10.1021\/ja9724957 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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2.<\/strong> Park, T. K.; Kim, I. J.; Hu, S.; Bilodeau, M. T.; Randolf, J. T.; Kwon, O.; Danishefsky, S. J. Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen. J. Am. Chem. Soc.<\/em> 1996<\/strong>, 118<\/em>, 11488\u201311500. DOI: 10.1021\/ja962048b [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

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1. <\/strong>Lee, E.; Lee, Y. R.; Moon, B.; Kwon, O.; Shim, M. S.; Yun, J. S. Oxyanion Orientation in Anionic Oxy-Cope Rearrangement. J. Org. Chem.<\/em> 1994<\/strong>, 59<\/em>, 1444\u20131456. DOI: 10.1021\/jo00085a037 [abstract<\/a>] [pdf]<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Publications – 122 122.\u00a0Dehnert, B. W.; Leung, C.; Kwon, O. Fluorodealkenylation: Ozonolysis and Treatment with FeII Salt and Selectfluor Convert […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-1151","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/pages\/1151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1151"}],"version-history":[{"count":95,"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/pages\/1151\/revisions"}],"predecessor-version":[{"id":1840,"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=\/wp\/v2\/pages\/1151\/revisions\/1840"}],"wp:attachment":[{"href":"https:\/\/kwonlab.chem.ucla.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}